The LILRB1 Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to CD85j, ILT2, and LILRB1. This antibody recognizes Human antigen. The LILRB1 Antibody (Center) has been validated for the following applications: ELISA, and Western Blot.
Description
This gene is a member of the leukocyte immunoglobulin-like
receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the
subfamily B class of LIR receptors which contain two or four
extracellular immunoglobulin domains, a transmembrane domain, and
two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
motifs (ITIMs). The receptor is expressed on immune cells where it
binds to MHC class I molecules on antigen-presenting cells and
transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and
cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different
isoforms have been found for this gene